Samirah Mustafa was born in Dhaka, Bangladesh and completed her primary education from Dhanmondi Government Girls High School, Dhaka. She got the primary govt. scholarship in class five.  She was also a debater in school and won her first Best Debater in parliamentary debate on BTV when she was in class eight. She had completed her B.Sc. and M.Sc. in Economics from Jahangirnagar University. In both B.Sc. and M.Sc. examinations she secured first class third position in her class.

After graduation she worked as a lecturer in Green University of Bangladesh in the department of Business Administration for two years from 1st January 2013 to 31st December 2014. Then she joined department of Economics in the Notre Dame University, Bangladesh.
She had received training on advanced research Methodology, Interactive teaching, Power-point presentation, How to do effective question in the examination etc. She has profound expertise in Mathematics for economics, Statistics, Econometrics, Advanced Macroeconomics, and Advanced Microeconomics, International economics. In the future she wants to do her research on these areas of Economics.